Glucocorticoid Regulation of Osteoclast Differentiation and Expression of Receptor Activator of Nuclear Factor-κB (NF-κB) Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Mouse Calvarial Bones
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منابع مشابه
Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation
C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and bone erosion in RA, in a conformation- and receptor activator of NF-κB ligand (RANKL)-dependent manner. CRP in the native conformation is ineffective, whe...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2006
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2005-0717